Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells.

@article{Goldstein1994ImmunizationWW,
  title={Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells.},
  author={Simoy Goldstein and William R. Elkins and William T London and Angelika Hahn and Robert M Goeken and Janice E. Martin and Vanessa M Hirsch},
  journal={Journal of medical primatology},
  year={1994},
  volume={23 2-3},
  pages={
          75-82
        }
}
Homologous SIVsm stocks were generated by passage of a macaque isolate of SIVsm (SIVsm/E660) in human CEM x 174 cells or macaque peripheral blood mononuclear cells. Macaques were immunized with whole inactivated SIV vaccine consisting of virus generated by transfection of CEM x 174 cells with the SIVsmH4 clone and were challenged with either cell-free stock. Only vaccinees challenged with virus generated in human cells were protected from infection. This confirms the species-specificity of… CONTINUE READING

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