Immunization with truncated envelope protein of Zika virus induces protective immune response in mice

@inproceedings{Han2017ImmunizationWT,
  title={Immunization with truncated envelope protein of Zika virus induces protective immune response in mice},
  author={Jian-feng Han and Yang Qiu and Jiu-Yang Yu and Hong-jiang Wang and Yong-qiang Deng and Xiao-Feng Li and Hui Zhao and Han-Xiao Sun and Chengfeng Qin},
  booktitle={Scientific Reports},
  year={2017}
}
The global spread of Zika virus (ZIKV) as well as its unexpected link to infant microcephaly have resulted in serious public health concerns. No antiviral drugs against ZIKV is currently available, and vaccine development is of high priority to prepare for potential ZIKV pandemic. In the present study, a truncated E protein with the N-terminal 90% region reserved (E90) from a contemporary ZIKV strain was cloned and expressed in Escherichia coli, purified by a Ni-NTA column, and characterized by… CONTINUE READING
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