Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis.

@article{ZadehVakili2004ImmunizationWT,
  title={Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis.},
  author={Azita Zadeh-Vakili and Tahere Taheri and Yasaman Taslimi and Fatemeh Doustdari and Ali Hatef Salmanian and Sima Rafati},
  journal={Vaccine},
  year={2004},
  volume={22 15-16},
  pages={1930-40}
}
Cysteine proteinases (CPs) are enzymes that belong to the papain superfamily, which are found in a number of organisms from prokaryotes to mammals. On the parasitic protozoan Leishmania, extensive studies have shown that CPs are involved in parasite survival, replication and the onset of disease, and have, therefore, been considered as attractive drugs and/or vaccine targets for the control of leishmaniasis. We have previously shown that cysteine proteinases, Type I (CPB) and Type II (CPA), in… CONTINUE READING

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