Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model.

@article{Rajapakse2002ImmunizationWT,
  title={Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model.},
  author={Palandage Sunethra Rajapakse and Neil M O'Brien-Simpson and Nada Slakeski and Brigitte Hoffmann and Eric C Reynolds},
  journal={Infection and immunity},
  year={2002},
  volume={70 5},
  pages={2480-6}
}
A major virulence factor of Porphyromonas gingivalis is the extracellular noncovalently associated complexes of Arg-X- and Lys-X-specific cysteine proteinases and adhesins designated the RgpA-Kgp complexes. In this study we investigated the ability of RgpA-Kgp as an immunogen to protect against P. gingivalis-induced periodontal bone loss in the rat. Specific-pathogen-free Sprague-Dawley rats were immunized with either formalin-killed whole P. gingivalis ATCC 33277 cells with incomplete Freund's… CONTINUE READING
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Cardiovascular disease and periodontal disease: microbial direct toxic effects on endothelial cells

  • E. C. Reynolds, N. M. O’Brien-Simpson
  • Periodontology
  • 2000

Characterization of a Porphyromonas gene prtK that encodes a lysine-specific cysteine proteinase and three sequence-related adhesins

  • N. Slakeski, S. M. Clean, P. S. Bhogal, E. C. Reynolds
  • Oral Microbiol. Immunol
  • 1999

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