Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid.

@article{Afonina2006ImmunizationWT,
  title={Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid.},
  author={Galyna Afonina and Isabelle Leduc and Igor Nepluev and Chrystina Jeter and Patty A Routh and Glen W. Almond and Paul E. Orndorff and Marcia M. Hobbs and Christopher Elkins},
  journal={Infection and immunity},
  year={2006},
  volume={74 4},
  pages={
          2224-32
        }
}
The etiologic agent of chancroid is Haemophilus ducreyi. To fulfill its obligate requirement for heme, H. ducreyi uses two TonB-dependent receptors: the hemoglobin receptor (HgbA) and a receptor for free heme (TdhA). Expression of HgbA is necessary for H. ducreyi to survive and initiate disease in a human model of chancroid. In this study, we used a swine model of H. ducreyi infection to demonstrate that an experimental HgbA vaccine efficiently prevents chancroid, as determined by several… CONTINUE READING

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