Immunization with recombinant bivalent chimera r-Cpae confers protection against alpha toxin and enterotoxin of Clostridium perfringens type A in murine model.

@article{Shreya2015ImmunizationWR,
  title={Immunization with recombinant bivalent chimera r-Cpae confers protection against alpha toxin and enterotoxin of Clostridium perfringens type A in murine model.},
  author={Das Shreya and Siva Ramakrishna Uppalapati and Joseph Jeyabalaji Kingston and Murali Harishchandra Sripathy and Harsh Vardhan Batra},
  journal={Molecular immunology},
  year={2015},
  volume={65 1},
  pages={51-7}
}
Clostridium perfringens type A, an anaerobic pathogen is the most potent cause of soft tissue infections like gas gangrene and enteric diseases like food poisoning and enteritis. The disease manifestations are mediated via two important exotoxins, viz. myonecrotic alpha toxin (αC) and enterotoxin (CPE). In the present study, we synthesized a bivalent chimeric protein r-Cpae comprising C-terminal binding regions of αC and CPE using structural vaccinology rationale and assessed its protective… CONTINUE READING
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