Immunization with recombinant Salmonella expressing SspH2-EscI protects mice against wild type Salmonella infection

@inproceedings{Hu2018ImmunizationWR,
  title={Immunization with recombinant Salmonella expressing SspH2-EscI protects mice against wild type Salmonella infection},
  author={Maozhi Hu and Weixin Zhao and Hongying Li and Jie Gu and Qiuxiang Yan and Xiaohui Zhou and Zhiming Pan and Guiyou Cui and Xin-an Jiao},
  booktitle={BMC veterinary research},
  year={2018}
}
BACKGROUND Enhancing caspase-1 activation in macrophages is helpful for the clearance of intracellular bacteria in mice. Our previous studies have shown that EscI, an inner rod protein of type III system in E. coli can enhance caspase-1 activation. The purpose of this study was to further analyze the prospect of EscI in the vaccine design. RESULTS A recombinant Salmonella expressing SspH2-EscI fusion protein using the promotor of Salmonella effector SspH2, X4550(pYA3334-P-SspH2-EscI), was… CONTINUE READING