Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus.

@article{Castan1999ImmunizationWP,
  title={Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus.},
  author={Sonia Casta{\~n}{\'o}n and M Soledad Mar{\'i}n and Jos{\'e} Manuel Mart{\'i}n-Alonso and Jos{\'e} Antonio Boga and R C B Casais and Jaime M. Humara and Ricardo Javier Ord{\'a}s and Francisco Vargas Parra},
  journal={Journal of virology},
  year={1999},
  volume={73 5},
  pages={4452-5}
}
The major structural protein VP60 of rabbit hemorrhagic disease virus (RHDV) has been produced in transgenic potato plants under the control of a cauliflower mosaic virus 35S promoter or a modified 35S promoter that included two copies of a strong transcriptional enhancer. Both types of promoters allowed the production of specific mRNAs and detectable levels of recombinant VP60, which were higher for the constructs carrying the modified 35S promoter. Rabbits immunized with leaf extracts from… CONTINUE READING