Immunization with peptides derived from the idiotypic region of lupus-associated autoantibodies delays the development of lupus nephritis in the (SWR x NZB)F1 murine model.

@article{Stoll2007ImmunizationWP,
  title={Immunization with peptides derived from the idiotypic region of lupus-associated autoantibodies delays the development of lupus nephritis in the (SWR x NZB)F1 murine model.},
  author={Matthew L Stoll and Karen D Price and Christopher Silvin and Feng Jiang and Jerrie Gavalchin},
  journal={Journal of autoimmunity},
  year={2007},
  volume={29 1},
  pages={
          30-7
        }
}
Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease affecting 40-50/100,000 Americans. Although most of the research on pathogenic antibodies focuses on antigenic specificity, there is increasing evidence that specific immunoglobulin idiotypes may mediate lupus nephritis independent of autoantigen specificity. In previous work, our laboratory characterized a set of nephritogenic monoclonal antibodies with substantial idiotypic cross-reactivity, produced by the spontaneous SLE… CONTINUE READING

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