Immunization with ovarian autoantigens leads to reduced fertility in mice following follicular dysfunction.

@article{Mande2012ImmunizationWO,
  title={Immunization with ovarian autoantigens leads to reduced fertility in mice following follicular dysfunction.},
  author={Purvi V. Mande and Susan L Thomas and Shagufta Khan and Sudhir L Jadhav and Vrinda V. Khole},
  journal={Reproduction},
  year={2012},
  volume={143 3},
  pages={309-23}
}
Immunoproteomics using sera of women with ovarian autoimmune diseases such as primary ovarian insufficiency and IVF embryo transfer recruits led to identification of three proteins namely alpha actinin 4 (α-ACTN4), heat-shock 70 protein 5 (HSPA5), and actin beta (ACTB). This study deals with the establishment of a peptide ELISA for screening sera of antiovarian antibody (AOA)-positive patients and further delves into understanding the role of these three proteins in ovarian autoimmunity in a… CONTINUE READING