Immunization with hepatitis C virus core gene triggers potent T-cell response, but affects CD4+ T-cells.

@article{Isaguliants2004ImmunizationWH,
  title={Immunization with hepatitis C virus core gene triggers potent T-cell response, but affects CD4+ T-cells.},
  author={Maria G Isaguliants and Natalia V Petrakova and Elena Kashuba and Yulia G Suzdaltzeva and Sergey V. Belikov and Vladislav V. Mokhonov and Alexei G. Prilipov and Ludmila Matskova and Irina S. Smirnova and Colette Jolivet-Reynaud and Erik Nordenfelt},
  journal={Vaccine},
  year={2004},
  volume={22 13-14},
  pages={
          1656-65
        }
}
Numerous attempts to induce immunity against HCV core (HCV-C) by DNA immunization met serious difficulties in optimizing T-helper cell and antibody responses. Immunomodulatory properties of HCV-C could be blamed that seem to be dependent on the genotype of HCV source. Here, we characterized HCV-C gene from HCV 1b isolate 274933RU. Eukaryotic expression of HCV-C was effectively driven by CMVIE, while human elongation factor 1 alpha promoter directed low levels of HCV-C expression. C57BL/6 mice… CONTINUE READING

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