Immunization with aspartate-β-hydroxylase-loaded dendritic cells produces antitumor effects in a rat model of intrahepatic cholangiocarcinoma.

@article{Noda2012ImmunizationWA,
  title={Immunization with aspartate-β-hydroxylase-loaded dendritic cells produces antitumor effects in a rat model of intrahepatic cholangiocarcinoma.},
  author={Takehiro Noda and Masafumi Shimoda and Vivian Ortiz and Alphonse E. Sirica and Jack R Wands},
  journal={Hepatology},
  year={2012},
  volume={55 1},
  pages={
          86-97
        }
}
UNLABELLED Dendritic cells (DCs) capture and process proteins and present peptides on the cell surface in the context of major histocompatibility complex I and II molecules to induce antigen-specific T cell immune responses. The aims of this study were to (1) employ an expanded and purified DC population and load them with aspartate-β-hydroxylase (ASPH), a highly expressed tumor-associated cell surface protein, and (2) to determine if immunization induced antitumor effects in an orthotopic rat… CONTINUE READING
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