Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease.

@article{Netland2010ImmunizationWA,
  title={Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease.},
  author={Jason M. Netland and Marta L. DeDiego and Jincun Zhao and Craig Fett and Enrique L Alvarez and Jose L. Nieto-Torres and Luis Enjuanes and Stanley Perlman},
  journal={Virology},
  year={2010},
  volume={399 1},
  pages={120-8}
}
The severe acute respiratory syndrome coronavirus (SARS-CoV) caused substantial morbidity and mortality in 2002-2003. Deletion of the envelope (E) protein modestly diminished virus growth in tissue culture but abrogated virulence in animals. Here, we show that immunization with rSARS-CoV-DeltaE or SARS-CoV-Delta[E,6-9b] (deleted in accessory proteins (6, 7a… CONTINUE READING