Immunization with an HIV-1 immunogen induces CD4+ and CD8+ HIV-1-specific polyfunctional responses in patients with chronic HIV-1 infection receiving antiretroviral therapy.

@article{Valor2008ImmunizationWA,
  title={Immunization with an HIV-1 immunogen induces CD4+ and CD8+ HIV-1-specific polyfunctional responses in patients with chronic HIV-1 infection receiving antiretroviral therapy.},
  author={Larissa Valor and J. L. Galan Navarro and Javier Carbone and Carmen Rodr{\'i}guez-Sainz and Juana Mª Sancho Gil and Francisco Zamora L{\'o}pez and E Fernandez-cruz},
  journal={Vaccine},
  year={2008},
  volume={26 22},
  pages={
          2738-45
        }
}
Development of polyfunctional T lymphocyte responses is critical in the immunological response against HIV-1. Fifty-four HIV-1 infected patients receiving antiretroviral treatment (ART) and immunization with an HIV-1 immunogen or placebo, periodically every 3 months throughout a period of 36 months, were evaluated for the purposes of analysing the development of HIV-1-specific CD4+ and CD8+ responses. A significant increase of proliferating and IFN-gamma producing CD8+ HIV-1-specific T cells… CONTINUE READING
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