Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells.

@article{Moore1995ImmunizationWA,
  title={Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells.},
  author={Anna Moore and P Mcguirk and Sharon Adams and Wyeth Jones and J. Patrick McGee and Derek T O'hagan and Kingston H. G. Mills},
  journal={Vaccine},
  year={1995},
  volume={13 18},
  pages={1741-9}
}
One of the major obstacles to the development of successful recombinant vaccines against human immunodeficiency virus (HIV) and other intracellular pathogens is the identification of a safe and effective vaccine delivery system for the induction of cell mediated immunity with soluble protein antigens. In this study it was demonstrated that immunization with a recombinant HIV envelop (env) protein entrapped in biodegradable poly(lactide-co-glycolide) (PLG) microparticles induced consistent HIV… CONTINUE READING