Immunization with a live, attenuated simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV.

@article{Marthas1990ImmunizationWA,
  title={Immunization with a live, attenuated simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV.},
  author={Marta L. Marthas and S Sutjipto and J. R. Higgins and Barbara L. Lohman and J Torten and Paul A. Luciw and Preston A Marx and Niels C Pedersen},
  journal={Journal of virology},
  year={1990},
  volume={64 8},
  pages={3694-700}
}
An infectious, virulence-attenuated molecular clone of simian immunodeficiency virus (SIV), SIVMAC-1A11, was derived from an SIV isolate that causes fatal immunodeficiency in rhesus macaques. When inoculated intravenously in rhesus macaques, SIVMAC-1A11 induced transient viremia (1 to 6 weeks) without clinical disease and a persistent humoral antibody response. The antibodies were directed mainly against the viral envelope glycoproteins, as determined by immunoblots and virus neutralization… CONTINUE READING
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