Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene.

@article{Rowe2006ImmunizationWA,
  title={Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene.},
  author={Helen M Rowe and Luciene Lopes and Yasuhiro Ikeda and Ranbir Bailey and Isabelle Barde and Martin Zenke and Benjamin M. Chain and Mary K. L. Collins},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2006},
  volume={13 2},
  pages={310-9}
}
Lentiviral vectors encoding antigens are promising vaccine candidates because they transduce dendritic cells (DC) in vivo and prime CTL responses. Here we examine their stimulation of antigen-specific CD4(+) T cells, critical for protective immunity against tumors or infectious disease. We constructed lentiviral vectors (lentivectors) expressing ovalbumin, which was secreted (OVA), cytoplasmic (OVAcyt), or fused to either invariant chain (Ii-OVA) or transferrin receptor (TfR-OVA) sequences… CONTINUE READING

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