Immunization with a dominant-negative recombinant HSV type 1 protects against HSV-1 skin disease in guinea pigs.

@article{Brans2008ImmunizationWA,
  title={Immunization with a dominant-negative recombinant HSV type 1 protects against HSV-1 skin disease in guinea pigs.},
  author={Richard Brans and Elof Erik Eriksson and Feng Sheng Yao},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 12},
  pages={
          2825-32
        }
}
CJ9-gD belongs to a new class of replication-defective recombinant herpes simplex viruses (HSVs) type 1 that can function in trans to prevent the replication of wild-type HSV in co-infected cells. Furthermore, CJ9-gD cannot establish latent infection in vivo and it expresses high levels of the major HSV-1 antigen glycoprotein D immediately following infection. In this study we show that guinea pigs immunized with CJ9-gD developed at least 9,600-fold higher titers of HSV-1-specific… CONTINUE READING
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