Immunization with a DNA plasmid encoding the SAG1 (P30) protein of Toxoplasma gondii is immunogenic and protective in rodents.

@article{Angus2000ImmunizationWA,
  title={Immunization with a DNA plasmid encoding the SAG1 (P30) protein of Toxoplasma gondii is immunogenic and protective in rodents.},
  author={Craig Angus and D Klivington-Evans and Jitender Prakash Dubey and Joseph A Kovacs},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={181 1},
  pages={317-24}
}
Immunization with DNA can induce humoral and cell-mediated immune responses, both of which are important in conferring immunity to Toxoplasma gondii. The efficacy of genetic vaccination with a cDNA encoding the T. gondii SAG1 (P30) surface antigen was evaluated. Sera of immunized mice showed recognition of T. gondii tachyzoites by immunofluorescence and exhibited high titers of antibody to SAG1 by ELISA. SAG1-stimulated splenocytes from vaccinated mice produced primarily interferon-gamma and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Toxoplsamic encephalitis in children. JAMA 1941;116:801–7

  • AB Sabin
  • JID
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…