Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi

@inproceedings{Matos2017ImmunizationWT,
  title={Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi},
  author={Marina N Matos and Silvia In{\'e}s Cazorla and Kai Sven Schulze and Thomas Ebensen and Carlos Alberto Guzm{\'a}n and Emilio L Malchiodi},
  booktitle={PLoS neglected tropical diseases},
  year={2017}
}
The development of new adjuvants enables fine modulation of the elicited immune responses. Ideally, the use of one or more adjuvants should result in the induction of a protective immune response against the specific pathogen. We have evaluated the immune response and protection against Trypanosoma cruzi infection in mice vaccinated with recombinant Tc52 or its N- and C-terminal domains (NTc52 and CTc52) adjuvanted either with the STING (Stimulator of Interferon Genes) agonist cyclic di-AMP (c… CONTINUE READING
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