Immunization with Leishmania vaccine-alum-BCG and montanide ISA 720 adjuvants induces low-grade type 2 cytokines and high levels of IgG2 subclass antibodies in the vervet monkey (Chlorocebus aethiops) model.

@article{Mutiso2012ImmunizationWL,
  title={Immunization with Leishmania vaccine-alum-BCG and montanide ISA 720 adjuvants induces low-grade type 2 cytokines and high levels of IgG2 subclass antibodies in the vervet monkey (Chlorocebus aethiops) model.},
  author={Joshua Muli Mutiso and John Chege Macharia and Michael Muita Gicheru},
  journal={Scandinavian journal of immunology},
  year={2012},
  volume={76 5},
  pages={471-7}
}
The availability of hundreds of adjuvants has prompted a need for identifying rational standards for the selection of adjuvant formulation based on sound immunological principles for human vaccines. As cytokines elaborated by activated T cells are required for the regulation of isotype switch during B-cell development, a study of Th2 cytokines and subclass distribution of the antibodies may shed new light on the processes involved in the polarization of the immune responses during vaccination… CONTINUE READING
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A phase I clinical trial of a multi-epitope polypeptide TAB 9 combined with Montanide ISA 720 adjuvant in non-HIV-1 infected human volunteers

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