Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges.

@article{Bomsel2011ImmunizationWH,
  title={Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges.},
  author={Morgane Bomsel and Daniela Tudor and A Drillet and Annette Alfsen and Yonatan Ganor and M Roger and Nicolas Mouz and Mario Amacker and Anick Chalifour and Lorenzo Diomede and Gilles Devillier and Zhe Cong and Qiang Wei and Hong Gao and Chuan Qin and Gui-bo Yang and Rinaldo Zurbriggen and L Lopalco and Sylvain Fleury},
  journal={Immunity},
  year={2011},
  volume={34 2},
  pages={269-80}
}
Human immunodeficiency virus (HIV)-1 is mainly transmitted mucosally during sexual intercourse. We therefore evaluated the protective efficacy of a vaccine active at mucosal sites. Macaca mulatta monkeys were immunized via both the intramuscular and intranasal routes with an HIV-1 vaccine made of gp41-subunit antigens grafted on virosomes, a safe delivery carrier approved in humans with self-adjuvant properties. Six months after 13 vaginal challenges with simian-HIV (SHIV)-SF162P3, four out of… CONTINUE READING