Immunization with HBsAg-Fc fusion protein induces a predominant production of Th1 cytokines and reduces HBsAg level in transgenic mice.

@article{Meng2012ImmunizationWH,
  title={Immunization with HBsAg-Fc fusion protein induces a predominant production of Th1 cytokines and reduces HBsAg level in transgenic mice.},
  author={Zhe-feng Meng and Hua-Jing Wang and Xin Yao and Xuan-Yi Wang and Yu-mei Wen and Jian-xin Dai and You-hua Xie and Jian-qing Xu},
  journal={Chinese medical journal},
  year={2012},
  volume={125 18},
  pages={
          3266-72
        }
}
BACKGROUND The Fc receptor associated pathway might improve the immune responses against hepatitis B virus (HBV) as previously described by us. In addition, the Flt3 ligand (FL) has been reported to potentiate antigen presenting cells in vivo and may act as a potential adjuvant to boost antigen-specific immune responses. In this study, the immune efficacies of a set of fusion proteins of HBsAg and Fc and/or FL were evaluated in HBsAg transgenic mice. METHODS The fusion proteins composed of… CONTINUE READING