Immunization with Culex tarsalis mosquito salivary gland extract modulates West Nile virus infection and disease in mice.

@article{MachainWilliams2013ImmunizationWC,
  title={Immunization with Culex tarsalis mosquito salivary gland extract modulates West Nile virus infection and disease in mice.},
  author={Carlos I Machain-Williams and Krystle L. Reagan and Tian Wang and Nordin S. Zeidner and Carol D. Blair},
  journal={Viral immunology},
  year={2013},
  volume={26 1},
  pages={84-92}
}
Mosquito salivary proteins inoculated during blood feeding modulate the host immune response, which can contribute to the pathogenesis of viruses transmitted by mosquito bites. Previous studies with mosquito bite-naïve mice indicated that exposure to arthropod salivary proteins resulted in a shift toward a Th2-type immune response in flavivirus-susceptible mice but not flavivirus-resistant animals. In the study presented here, we tested the hypothesis that immunization with high doses of Culex… CONTINUE READING
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