Immunization using an Apo B-100 related epitope reduces atherosclerosis and plaque inflammation in hypercholesterolemic apo E (-/-) mice.

@article{Chyu2005ImmunizationUA,
  title={Immunization using an Apo B-100 related epitope reduces atherosclerosis and plaque inflammation in hypercholesterolemic apo E (-/-) mice.},
  author={K Y Chyu and Xiaoning Zhao and Odette S. Reyes and Stephanie M. Babbidge and Paul C Dimayuga and Juliana Yano and Bojan Cercek and Gunilla Nordin Fredrikson and Jan Nilsson and Prediman Krishan Shah},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={338 4},
  pages={
          1982-9
        }
}
Immune system modulates atherosclerosis and immunization using homologous LDL reduces atherosclerosis in hyperlipidemic animals. The nature of athero-protective antigenic epitopes in LDL remains unclear. We have recently identified nearly a 100 antigenic epitopes in human apo B-100 and in this study we evaluated the effects of immunization with two such epitopes on atherosclerosis in hypercholesterolemic apo E (-/-) mice. Male apo E (-/-) mice were immunized at 6-7 weeks of age with two… CONTINUE READING

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