Immunization to minor histocompatibility antigens on transfused RBCs through crosspriming into recipient MHC class I pathways.


Increased rates of graft rejection after bone marrow transplantation (BMT) are observed in patients whose illnesses--such as sickle cell disease, thalassemia, and aplastic anemia--necessitate chronic transfusion before BMT. Because BM transplants in these patients are routinely HLA matched, any immunization responsible for increased rejection is likely… (More)


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