Immunization of rhesus monkeys with a mucosal prime, parenteral boost strategy protects against infection with Helicobacter pylori.

@article{Lee1999ImmunizationOR,
  title={Immunization of rhesus monkeys with a mucosal prime, parenteral boost strategy protects against infection with Helicobacter pylori.},
  author={Cynthia K.S. Lee and Ken Soike and Paul J. Giannasca and Joseph A Hill and Richard Allen Weltzin and Harry Kleanthous and Jonathan Peter Blanchard and Thomas P Monath},
  journal={Vaccine},
  year={1999},
  volume={17 23-24},
  pages={
          3072-82
        }
}
Rhesus monkeys were immunized with recombinant Helicobacter pylori urease vaccine given solely by the parenteral route or preceded by a priming dose given by the oral route. Two groups of monkeys received parenteral urease with either a synthetic glycolipid adjuvant (Bay) or aluminum hydroxide (alum) as adjuvants. A third group of monkeys received a priming dose of oral urease given with the mucosal adjuvant LT (Escherichia coli heat labile enterotoxin), followed by parenterally administered… CONTINUE READING
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