Immunization of naive BALB/c mice with human beta2-glycoprotein I breaks tolerance to the murine molecule.


OBJECTIVE Immunization of naive mice with beta2-glycoprotein I (beta2GPI) leads to the generation of pathogenic anticardiolipin antibodies associated with clinical manifestations of the antiphospholipid syndrome (APS). The aim of this study was to determine whether immunization of naive mice with human beta2GPI, which shares homology with mouse beta2GPI… (More)