Immunization of mice with Lactobacillus casei expressing intimin fragments produces antibodies able to inhibit the adhesion of enteropathogenic Escherichia coli to cultivated epithelial cells.

@article{Ferreira2008ImmunizationOM,
  title={Immunization of mice with Lactobacillus casei expressing intimin fragments produces antibodies able to inhibit the adhesion of enteropathogenic Escherichia coli to cultivated epithelial cells.},
  author={Patr{\'i}cia Cristina Duarte Ferreira and Ivana Barros de Campos and Cec{\'i}lia Mari Abe and Luiz Rachid Trabulsi and Waldir P Elias and P L Ho and Maria Leonor S Oliveira},
  journal={FEMS immunology and medical microbiology},
  year={2008},
  volume={54 2},
  pages={
          245-54
        }
}
Enteropathogenic Escherichia coli (EPEC) are frequently isolated as a cause of infantile diarrhea in developing countries. Its pathogenicity is distinguished by histopathological alterations at the site of infection, known as attaching and effacing (A/E) lesions, in which bacterial virulence factors and host proteins participate. Intimin, a bacterial adhesin expressed by all EPEC described to date, is responsible for the intimate adherence of the bacteria to host cells and is essential for the… CONTINUE READING
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