Immunization of mice with DNA-based Pfs25 elicits potent malaria transmission-blocking antibodies.

@article{Lobo1999ImmunizationOM,
  title={Immunization of mice with DNA-based Pfs25 elicits potent malaria transmission-blocking antibodies.},
  author={Cheryl Ann Lobo and Ravi Dhar and Nirbhay Kumar},
  journal={Infection and immunity},
  year={1999},
  volume={67 4},
  pages={1688-93}
}
Immunological intervention, in addition to vector control and malaria chemotherapy, will be needed to stop the resurgence of malaria, a disease with a devastating impact on the health of 300 to 500 million people annually. We have pursued a vaccination strategy, based on DNA immunization in mice with genes encoding two antigens present on the sexual stages of Plasmodium falciparum, Pfs25 and Pfg27, to induce biologically important antibodies that can block development of the parasite in the… CONTINUE READING

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