Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection.

Abstract

Respiratory syncytial virus (RSV) is a major cause of severe respiratory disease in infants and the elderly. RSV vaccine development has been hampered by results of clinical trials in the 1960s, when formalin-inactivated whole-RSV preparations adjuvated with alum (FI-RSV) were found to predispose infants for enhanced disease following subsequent natural RSV… (More)

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@article{Swart2002ImmunizationOM, title={Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection.}, author={Rik L de Swart and Thijs Kuiken and Helga H. Timmerman and Geert van Amerongen and Bernadette G. van den Hoogen and Helma W Vos and Herman J Neijens and Arno C. Andeweg and Albert D M E Osterhaus}, journal={Journal of virology}, year={2002}, volume={76 22}, pages={11561-9} }