Immunization of chimpanzees with hepatitis B virus-derived polypeptides.


Previous studies established that the purified polypeptides derived from the 22-nm particles associated with hepatitis B surface antigen (HBsAg) produce both humoral and cellular immunity against HBsAg in guinea pigs. Therefore, the two major polypeptides with molecular weights of 22,000 and 25,000 (P22 and P25, respectively) were isolated, adsorbed to an… (More)


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@article{Dreesman1981ImmunizationOC, title={Immunization of chimpanzees with hepatitis B virus-derived polypeptides.}, author={Gordon R. Dreesman and F. Blaine Hollinger and Yolanda Anita Sanchez and Paul E Oefinger and Joseph L. Melnick}, journal={Infection and immunity}, year={1981}, volume={32 1}, pages={62-7} }