Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease.

@article{Michetti1994ImmunizationOB,
  title={Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease.},
  author={Pierre Michetti and Ir{\`e}ne E Corth{\'e}sy-Theulaz and Colleen Davin and Rainer Haas and A C Vaney and Markus Heitz and Jacques Bille and J. P. Kraehenbuhl and Emilia Saraga and Andr{\'e} Louis Blum},
  journal={Gastroenterology},
  year={1994},
  volume={107 4},
  pages={
          1002-11
        }
}
BACKGROUND/AIMS Because Helicobacter pylori is a potentially dangerous human pathogen, the protective potential of oral immunization with H. pylori urease and its subunits was evaluated in an animal model. METHODS Mice were orally immunized with H. pylori sonicate, urease, or recombinant enzymatically inactive urease subunits and then challenged with Helicobacter felis. Control mice were sham-immunized. RESULTS H. felis colonization was present 5 days after challenge in 9 of 10 sham… CONTINUE READING
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