Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection.

@article{Costa1999ImmunizationAG,
  title={Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection.},
  author={X J Da Costa and Carol A. Jones and David Michael Knipe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 12},
  pages={6994-8}
}
An effective vaccine for genital herpes has been difficult to achieve because of the limited efficacy of subunit vaccines and the safety concerns about live viruses. As an alternative approach, mutant herpes simplex virus strains that are replication-defective can induce protective immunity. To increase the level of safety and to prove that replication was not needed for immunization, we constructed a mutant herpes simplex virus 2 strain containing two deletion mutations, each of which… CONTINUE READING

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Da Costa et al

Letvin, N. L. Science 280, 1875–1880. 6998 Microbiology
Proc. Natl. Acad. Sci. USA 96 • 1999
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