Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen.

@article{Duc2007ImmunizationAA,
  title={Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen.},
  author={Le Hong Duc and Huynh A. Hong and Helen Atkins and Helen C Flick-Smith and Zarmina Durrani and Sjoerd G. T. Rijpkema and Richard W. Titball and Simon M Cutting},
  journal={Vaccine},
  year={2007},
  volume={25 2},
  pages={346-55}
}
Protective immunity to anthrax can be achieved by antibodies raised against the secreted protective antigen (PA) and this forms the basis of the current acellular vaccines for human use. Bacillus subtilis spores have previously been used for delivery of heterologous antigens by the oral and nasal routes and their intrinsic heat-stability make them attractive vaccine vehicles. In this study we have expressed PA, or segments of PA, in B. subtilis using two strategies. First, display on the spore… CONTINUE READING

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