Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory.

@article{Brndler1996ImmunityTV,
  title={Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory.},
  author={Marie Anne Br{\"u}ndler and Peter Aichele and Michael Bachmann and Daisuke Kitamura and K. Rajewsky and Rolf Martin Zinkernagel},
  journal={European journal of immunology},
  year={1996},
  volume={26 9},
  pages={2257-62}
}
Mice rendered B cell deficient by targeted disruption of the immunoglobulin mu chain gene (IgM-/- mice) were used to analyze the role of antibodies and B cells in viral infections; homozygous IgM-/- mice were bred in a way to avoid transmission of maternal antibodies. After infection with vesicular stomatitis virus (VSV), IgM-/- mice developed paralytic disease and subsequently died, whereas C57BL/6 control mice or IgM-/- mice passively protected with VSV-neutralizing antibodies survived… CONTINUE READING