Immunity to polyomavirus infection: the polyomavirus-mouse model.

  title={Immunity to polyomavirus infection: the polyomavirus-mouse model.},
  author={Phillip A. Swanson and Aron E Lukacher and Eva Szomolanyi-Tsuda},
  journal={Seminars in cancer biology},
  volume={19 4},
A ubiquitous clinically silent murine pathogen, polyomavirus has enjoyed long-term co-evolution with the mouse, a highly tractable and genetically and immunologically informative small animal model. Thus, polyomavirus has provided a valuable experimental construct to decipher the host immune mechanisms that come into play to control systemic low-level persistent viral infections. Impaired immunosurveillance for infected cells puts the murine host at risk both to injury resulting from excessive… CONTINUE READING


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