Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum.

@article{Pombo2002ImmunityTM,
  title={Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum.},
  author={David J. Pombo and Gregor Lawrence and Chakrit Hirunpetcharat and Christine M. Rzepczyk and Michelle D. Bryden and Nicole Cloonan and Karen Anderson and Yuvadee Mahakunkijcharoen and Laura B. Martin and Danny W. Wilson and Salenna R. Elliott and Suzanne Elliott and Damon P. Eisen and J Brice Weinberg and A Tova Saul and Michael F Good},
  journal={Lancet},
  year={2002},
  volume={360 9333},
  pages={610-7}
}
BACKGROUND The ability of T cells, acting independently of antibodies, to control malaria parasite growth in people has not been defined. If such was shown to be effective, an additional vaccine strategy could be pursued. Our aim was to ascertain whether or not development of cell-mediated immunity to Plasmodium falciparum blood-stage infection could be induced in human beings by exposure to malaria parasites in very low density. METHODS We enrolled five volunteers from the staff at our… CONTINUE READING
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