Immunity to citrullinated proteins in rheumatoid arthritis.


Antibodies to citrullinated proteins (ACPA), i.e., to peptides posttranslationally modified by the conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis (RA). Studies on anticitrulline immunity, summarized in this review, demonstrate that the criterion-based syndrome RA should be subdivided into at least two… (More)
DOI: 10.1146/annurev.immunol.26.021607.090244


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@article{Klareskog2008ImmunityTC, title={Immunity to citrullinated proteins in rheumatoid arthritis.}, author={Lars Klareskog and Johan R{\"o}nnelid and Karin Lundberg and Leonid Padyukov and Lars S Alfredsson}, journal={Annual review of immunology}, year={2008}, volume={26}, pages={651-75} }