Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets

  title={Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets},
  author={Jens Geginat and Giulia Nizzoli and Moira Paroni and Stefano Maglie and Paola Larghi and Steve Pascolo and Sergio Abrignani},
  booktitle={Front. Immunol.},
Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have a key role in immune responses because they bridge the innate and adaptive arms of the immune system. They mature upon recognition of pathogens and upregulate MHC molecules and costimulatory receptors to activate antigen-specific CD4(+) and CD8(+) T cells. It is now well established that DCs are not a homogeneous population but are composed of different subsets with specialized functions in immune responses to… CONTINUE READING
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