Immunity of fungal infections alleviated graft reject in liver transplantation compared with non-fungus recipients.

Abstract

OBJECTIVE To evaluate of the immune tolerance in adult LT recipients with Invasive fungal infections (IFIs). METHODS 109 consecutive LT recipients who received LT were included. Percentage of T subsets (CD4+CD25hiCD127- T cells, CD4+CD25loCD45RA+ T cells, CD4+CD25loCD45RA- and CD4+CD45RA-CD45RO+ T cells populations), levels of cytokines (IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ, IL-12p70, IL-17, TNF-α, TNF-β and GM-CSF) were detected by FACS and Bioplex in peripheral blood. Biopsy specimens were fixed, monoclonal antibodies against CD4, Foxp3 and IL-17 were applied to the above sections and FISH was performed. RESULTS The risk of acute rejection was decreased in fungal infected liver transplant recipients comparing with non-fungal infected group. CD4+CD25hiCD127T cell population was increased in peripheral blood and memory CD4+CD45RA-CD45RO+ T cell population decreased. There was significant lower levels observed in naïve CD4+CD25loCD45RA+ and CD4+CD25loCD45RA- T cell populations in fungal infected liver transplant. Moreover, IL-2, IL-6, IL-10 and GM-CSF were decreased. However, no significant difference with IL-4 and IL-8 in serum in two infected LT recipients. CONCLUSION The incidence of graft rejection in liver transplantation recipients with fungal infections was lower than the non-fungal group. It is important to assess the risk during pretransplant and postoperation for liver transplantation.

Cite this paper

@article{Xing2015ImmunityOF, title={Immunity of fungal infections alleviated graft reject in liver transplantation compared with non-fungus recipients.}, author={Tong-hai Xing and Lin Zhong and Lihui Lin and Guoqiang Qiu and Zhihai Peng}, journal={International journal of clinical and experimental pathology}, year={2015}, volume={8 3}, pages={2603-14} }