Immunity in human schistosomiasis mansoni: cross-reactive IgM and IgG2 anti-carbohydrate antibodies block the expression of immunity.

@article{Butterworth1988ImmunityIH,
  title={Immunity in human schistosomiasis mansoni: cross-reactive IgM and IgG2 anti-carbohydrate antibodies block the expression of immunity.},
  author={Anthony E. Butterworth and David W. Dunne and Anthony J. C. Fulford and Monique Capron and Jamal Khalife and Andr{\'e} Capron and Davy Koech and John Henry Ouma and Robert F Sturrock},
  journal={Biochimie},
  year={1988},
  volume={70 8},
  pages={1053-63}
}
We have previously reported that the slow development of immunity to reinfection after treatment of Schistosoma mansoni infections is partly attributable to the continued presence of 'blocking' antibodies in young, susceptible children. A further analysis of this phenomenon supports the hypothesis that such blocking antibodies can be of the IgG2 as well as the IgM isotype, and that they react with carbohydrate epitopes expressed both on egg polysaccharides and on schistosomulum surface antigens… CONTINUE READING

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