Immunity and counter-immunity during infection with the parapoxvirus orf virus.

@article{Haig2002ImmunityAC,
  title={Immunity and counter-immunity during infection with the parapoxvirus orf virus.},
  author={David M. Haig and Colin J McInnes},
  journal={Virus research},
  year={2002},
  volume={88 1-2},
  pages={3-16}
}
Orf virus is a DNA parapoxvirus that causes orf, an acute debilitating skin disease of sheep, goats and humans. In sheep, a vigorous immune response involving neutrophils, dermal dendritic cells, T cells, B cells and antibody is generated after infection. CD4(+) T cells, IFN-gamma and to a lesser extent CD8(+) T cells are involved in partial protection against infection. In spite of this, orf virus can repeatedly infect sheep albeit with reduced lesion size and time to resolution compared to… CONTINUE READING

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