Immunisation with a combination of two complementary feline calicivirus strains induces a broad cross-protection against heterologous challenges.

@article{Poulet2005ImmunisationWA,
  title={Immunisation with a combination of two complementary feline calicivirus strains induces a broad cross-protection against heterologous challenges.},
  author={H. Poulet and Sylvie Brunet and Vincent Leroy and Gilles Chappuis},
  journal={Veterinary microbiology},
  year={2005},
  volume={106 1-2},
  pages={17-31}
}
Feline calicivirus (FCV) is characterised by a high degree of antigenic variation potentially compromising vaccine efficacy. Inclusion of several FCV strains or antigens in current vaccines could be a means to improve protection against antigenically distinct isolates. This study evaluated the synergy between two FCV strains (FCVG1 and FCV431) by comparing immunity induced by either strain with that provided by a combination of the two strains against an heterologous challenge with… CONTINUE READING

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