Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen.

@article{Londoo1996ImmunisationOM,
  title={Immunisation of mice using Salmonella typhimurium expressing human papillomavirus type 16 E7 epitopes inserted into hepatitis B virus core antigen.},
  author={L P Londo{\~n}o and Steven N Chatfield and Robert W. Tindle and K. Herd and Xiao Ming Gao and Ian Frazer and Gordon Dougan},
  journal={Vaccine},
  year={1996},
  volume={14 6},
  pages={545-52}
}
Live vaccines based on BRD509, an attenuated S. typhimurium (aroA, aroD) strain, were constructed that directed the expression of hepatitis B core antigen particles (HBcAg) (BRD969) or HBcAg harbouring human papillomavirus type 16 E7 protein sequences (BRD974), under the control of the in vivo inducible nirB promoter. These strains were used to orally or intravenously immunise different inbred mouse strains and humoral, secretory and cellular anti-E7 and anti-HBcAg responses were monitored… CONTINUE READING
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