Immunisation of macaques with SIV env recombinants: specificity of T cell and antibody responses and evaluation of protective efficacy.

@article{Mills1993ImmunisationOM,
  title={Immunisation of macaques with SIV env recombinants: specificity of T cell and antibody responses and evaluation of protective efficacy.},
  author={Kingston H G Mills and Mark C Page and P A Kitchin and L. M. Chan and Walis Jones and Peter M Silvera and Terry Corcoran and Bernadine Flanagan and Changquan Ling and Clotilde Thiriart},
  journal={Journal of medical primatology},
  year={1993},
  volume={22 2-3},
  pages={104-9}
}
Macaques were immunised with lentil lectin purified recombinant SIVmac (BK28) derived gp160 (rgp160) with or without live vaccinia (vac)-env (BK28) priming, followed by a final boost with solid matrix antibody antigen (SMAA)-gp160 (J5) complexes and challenged with the SIVmac molecularly cloned virus J5M. Rgp160 and vac-env plus gp160 induced strong Ab responses against the homologous virus. Live vac-env did not enhance or prolong the antibody response, however, T cell responses were stronger… CONTINUE READING