Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.

@article{Salehin2011ImmunhistochemicalAF,
  title={Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.},
  author={Darius Salehin and Iris Fromberg and Christina Haugk and Birgit Dohmen and Thomas Georg and Rainer Bohle and Dirk Olaf Bauerschlag and Marc Thill and Michael Friedrich},
  journal={European journal of gynaecological oncology},
  year={2011},
  volume={32 6},
  pages={628-35}
}
Calpains, also called calcium activated neutral proteases (CANP), are expressed ubiquitously. They are intracellular, non-lysosomal cytoplasmic cysteine endopeptidases. Calcium is required for their activation. Their endogenous specific inhibitor is calpastatin, which is expressed ubiquitously and coexists within cells besides calpain. When calcium is present, calpastatin and calpain attach to each other inhibiting the protease. The calpain system plays an important role in many processes… CONTINUE READING

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