Immune tolerance in hemophilia with factor VIII inhibitors: predictors of success.

@article{Mariani2001ImmuneTI,
  title={Immune tolerance in hemophilia with factor VIII inhibitors: predictors of success.},
  author={Guglielmo Mariani and Barbara L. Kroner},
  journal={Haematologica},
  year={2001},
  volume={86 11},
  pages={1186-93}
}
BACKGROUND AND OBJECTIVES Long term administration of high doses of factor VIII (FVIII) was shown to eliminate alloantibodies to FVIII (FVIII inhibitors). This procedure is widely referred to as immune tolerance (IT). DESIGN AND METHODS In 1989 an international registry of IT protocols was created which recruited 314 patients with severe hemophilia A (HA) and an inhibitor who were given IT treatment. RESULTS Fifty hemophilia care centers worldwide contributed data to the registry; 94.8% of… CONTINUE READING

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