Immune tolerance and control of CNS autoimmunity: from animal models to MS patients.

@article{Cassan2007ImmuneTA,
  title={Immune tolerance and control of CNS autoimmunity: from animal models to MS patients.},
  author={C{\'e}cile Cassan and Roland S Liblau},
  journal={Journal of neurochemistry},
  year={2007},
  volume={100 4},
  pages={883-92}
}
Multiple sclerosis (MS) is a chronic inflammatory disease resulting in demyelination and axonal loss within the CNS. An autoimmune reaction directed against myelin antigens contributes to the disease process. As the CNS has long been considered an immune privileged site, how such an immune response can develop locally has remained enigmatic. Recent data, mostly based on the study of animal models for MS, have shown that the CNS is in fact more permissive to the development of immune responses… CONTINUE READING
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