Immune tolerance: what is unique about the liver.

@article{Tiegs2010ImmuneTW,
  title={Immune tolerance: what is unique about the liver.},
  author={G. Tiegs and A. Lohse},
  journal={Journal of autoimmunity},
  year={2010},
  volume={34 1},
  pages={
          1-6
        }
}
The 'liver tolerance effect' mediates local and systemic tolerance to self and foreign antigens and has been attributed to specialized resident cells expressing anti-inflammatory mediators and inhibitory cell surface ligands for T cell activation. Non-parenchymal liver cells responsible for the tolerogenic properties of the liver are the resident dendritic cells (DCs), which comprise myeloid as well as plasmacytoid DCs, liver sinusoidal endothelial cells (LSECs), Kupffer cells (KCs) as well as… Expand
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